Investigation revealed that conolidine and cannabidiol appreciably blocked Cav2.2 channels. In the peripheral and central anxious system, Cav2.2 channels are located predominantly at presynaptic terminals32 and play crucial roles in suffering perception by modulating depolarization-induced calcium entry into neurons33,34. Compounds that influence presynaptic Cav2.2 channel activity or... https://is-conolidine-an-opiate60012.blogdun.com/27264349/5-essential-elements-for-conolidine