When switching a patient to liothyronine sodium, discontinue levothyroxine therapy and initiate liothyronine sodium in a lower dosage. Little by little improve the dose in accordance with the individual’s response (two.5) Phenytoin and carbamazepine lower serum protein binding of thyroid hormones, and total and FT4 may be lowered by 20% http://www.t3tiromel.com