Substitution at R3 having a halogen or alkoxy group (74f–74i) triggered a slight increase in mobile potency Along with the halide analogs (74g–h) exhibiting maximum the potency within the group. Additional optimization triggered the invention of 74i–j, with 74k as by far the most active compound in the sequence (pIC50 https://indazoleproducts43107.theobloggers.com/37620099/everything-about-indazole-3-carboxamide