You will find a release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to lower afferent agony transmission and create analgesia. For that reason, medicines like clonidine that concentrate on alpha-two receptors can influence the transmission of soreness. Applies to clonidine: https://alfredr728kbq3.activablog.com/profile